WheyCal ™

What is special about our WheyCal ™?
It is a natural calcium complex derived from fermented milk by means of a unique isolation process.

On a molecular level WheyCal ™ has a crystalline configuration whereas other Whey calcium products have an amorphous configuration. This is a consequence of our unique separation process. Crystalline Whey Calcium is actually a benefit. The different molecular configuration has a major impact on taste. Whereas a regular whey calcium product has a typical chalky or sandy taste. WheyCal ™ has a more milky or creamy sweet taste. WheyCal ™ will also dissolve quiet easily in liquids and stay in an ionic state.
It is evident without further science, that a drink that leaves less calcium residue in the bottle, stands a better chance of delivering high doses of calcium to the body.

Composition:
WheyCal ™ is a dairy ingredient that consists of milk minerals in concentrated form. It is made from cow’s milk and can be used in food products and dietary supplements. It is a rich source of Whey Calcium and contains a wide range of trace elements and minerals from milk.

WheyCal ™ offers the following benefits:
· Excellent taste
· Proven efficacy in bone health
· High consumer recognition and preference -‡ labeling benefits
· 100% natural
· 100% dairy
· Excellent source of Calcium
· Excellent source of Phosphorus
· Good source of Magnesium
· Easy to use

WheyCal ™
This product has excellent, milky and non-gritty taste due to its unique crystalline form. It contains 17% Calcium,

(Calcium enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind placebo-controlled trial, Journal of Clinical Investigation, 1997, 99:1287 -1294 and A significant effect of calcium enriched foods on bone mineral mass gain is maintained more than 3 years after discontinuation of intervention, Journal of Bone Mineral Research, 14, S185).

2. Is WheyCal ™ bioavailable?

Several studies show that Calcium from milk mineral complex has superior bioavailability.
In the last years a number of human studies have been completed that focused on the effect of dietary milk calcium on bone health and obesity:

In 2001, Kun et al. reviewed the effects of various trials with calcium-rich foods. This review also shows a very positive effect of dairy calcium on bone health and the prevention of osteoporosis. [1]

A rat study by Tsuchita et al in 1992 had already demonstrated that Calcium from whey mineral complex was more bioavailable than calcium carbonate.

Another study in prepubertal girls, who were given milk calcium enriched food products (Bonjour et al, 1997), did show a positive effect of milk calcium fortified products on skeletal growth and bone mass.

Mean BMD (Bone Mineral Density) gains in prepubertal girls consuming milk calcium enriched food products or placebos during 48 weeks.

In a double-blind placebo controlled study, 149 prepubertal girls (average age 7.9 yr.) were either given two milk Calcium enriched food products or non-enriched foods on a daily basis for 1 year. 108 girls completed the whole study period. Milk Calcium was used for enrichment of normal food products, including: cakes, biscuits, fruit juice, instant chocolate milk drink, chocolate bars and yogurt. The spontaneous Calcium intake in the control group was 879 mg Ca/day. The Calcium enriched foods accounted for an additional intake of 807 mg which adds up to a total intake of 1723 mg Ca/day for the Calcium supplemented group. Bone mineral density (BMD), bone mineral content (BMC) and bone size were determined during the study.

This study is especially valuable, since: Calcium derived from Whey extracts were used by (Bonjour et al, 1997). They appear to exert an anabolic effect on the growing skeleton.
1. Bonjour used whey Calcium as a calcium source
2. The Bonjour study is a human study using normal food products as carriers for calcium supplementation;
The study clearly demonstrates a positive effect of Whey Calcium on bone mineral density, the nutri-tional effect we are actually looking for in relation to prevention of osteoporosis.

The conclusion of the study is two-fold:
1. There is a positive effect of Whey Calcium supplementation on bone mineral density
2. A greater benefit of Calcium supplementation was found in girls with a lower spontaneous Calcium intake

Applications

1. Functional foods: Drinks, powders, bars and capsules
2. Sports and body building drinks, powders, bars and capsules
3. Dietetic supplements and weight loss
4. Dairy products, milk shakes and fermented milk products
5.Nutritional confectionery and baked products and cereals

Literature references:

1. Kun Z., Greenfield H., Xueqin D., Fraser D.R., 2001 Nutrition Research Reviews(June), 14 (1), 119-151 (215 ref.) “Improvement of bone health in childhood and adolescence.”

2. Durlach, Magnes Res 1989 Sep;2(3):195-203

3. FASEB J 2000 Jun;14(9):1132-8 “Regulation of adiposity by dietary calcium”, Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Department of Nutrition, The University of Tennessee, Knoxville, Tennessee 37996-1900, USA
4. Physiol Genomics 2000 Aug 9;3(2):75-82, “Role of intracellular calcium in human adipocyte differentiation”, Shi H, Halvorsen YD, Ellis PN, Wilkison WO, Zemel MB., Department of Nutrition, The University of Tennessee, Knoxville, Tennessee, 37996, USA

5. Am J Physiol 1997 Mar;272(3 Pt 1):E379-84, “Agouti regulation of intracellular calcium: role of melanocortin receptors”, Kim JH, Kiefer LL, Woychik RP, Wilkison WO, Truesdale A, Ittoop O, Willard D, Nichols J, Zemel MB., Department of Nutrition and Physiology Program, University of Tennessee, Knoxville 37996-1900, USA

6. G. M, Chan, University of Utah Hospitals and Clinics, American College of Nutrition annual meeting 2001, "The effects of dairy products on children's body fat”

7. Mol. Cell. Biochem. 1998 Nov;188(1-2):129-36 “Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension.”, Zemel MB, Department of Nutrition, University of Tennessee, Knoxville 37996-1900, USA.

8. “Facts about Dietary Supplements”, US Dept. of Health and Human services, National Institutes of Health.

9. J.P. Bonjour, A.L. Carrie et al. “Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double blind, placebo-controlled trial”, J. Clin. Invest. Vol 99(6) 1997, 1287 – 1294

10. Cumming et al. “calcium for prevention of osteoporotic fractures in postmenopausal women”, J Bone Miner Res 1997 (12) 1321-9

11. Baron et al. N.J.E.M. 199(340) 101-7

12. Van Beresteijn et al. Milk:does it affect blood pressure? A controlled intervention study. J. Intern. Med. 1990; 228 (5): 477-82.
13. Heaney, R.P. Calcium, Dairy Products and Osteoporosis. J. Am. College Nutr.2000; 19 (2): 83S-99S.

14. Recommended Dietary Allowances 10 th edition, National Academy Press, 1989

15. Tsuchita, H. et al. Bioavailabilities of calcium, phosphorus and magnesium from whey
mineral complex in growing male rats. Z. Ernährungswissenschaft (1992); 31: 258-268.

16. Bonjour, J.P. et al. Calcium-enriched Foods and Bone Mass Growth in Prepubertal Girls:
A Randomised, Double-blind, Placebo-controlled Trial.
J. Clinical Investigation (1997); 99:1287-1294.

17. Conference Report Food and Nutrition Board, National Academy of Sciences, National
Academy Press, Washington

18. Bovee-Oudenhoven, I. et al. Calcium in milk and fermentation by yoghurt bacteria increase
the resistance of rats to salmonella infection. Gut (1996); 38: 59-65.